RESUMO
During last years considerable interest has been devoted to understand the role of oxugen radicals in the inschemia induced cell injury associated with reperfusion. In the brain and in others tissues, free radicals play a role as modulators of vascular tone as well as a cytotoxic role as part of the ischemia associated pathology. This review discusses methods for free radical detection in brain and in other tissues, mechanisms of radical production in the course of the ischemia reperfusion process, and the efficacy of potential antioxidant agents in post ischemia therapy, especially with respect to allopurinol, an inhibitor of xanthine oxidase, and the role of taurine and its derivatives as antioxidants in different organs including the brain.
Assuntos
Antioxidantes/farmacologia , Inibidores Enzimáticos/farmacologia , Isquemia/metabolismo , Traumatismo por Reperfusão/metabolismo , Xantina Oxidase/antagonistas & inibidores , Xantina Oxidase/fisiologia , Niacinato de Xantinol , Radicais Livres/metabolismo , Isquemia/enzimologia , Isquemia/patologia , Neutrófilos/fisiologia , Espécies Reativas de Oxigênio/metabolismo , Traumatismo por Reperfusão/enzimologia , Traumatismo por Reperfusão/patologia , Taurina/metabolismoRESUMO
During last years considerable interest has been devoted to understand the role of oxugen radicals in the inschemia induced cell injury associated with reperfusion. In the brain and in others tissues, free radicals play a role as modulators of vascular tone as well as a cytotoxic role as part of the ischemia associated pathology. This review discusses methods for free radical detection in brain and in other tissues, mechanisms of radical production in the course of the ischemia reperfusion process, and the efficacy of potential antioxidant agents in post ischemia therapy, especially with respect to allopurinol, an inhibitor of xanthine oxidase, and the role of taurine and its derivatives as antioxidants in different organs including the brain. (AU)
Assuntos
Isquemia/metabolismo , Traumatismo por Reperfusão/metabolismo , Niacinato de Xantinol , Inibidores Enzimáticos/farmacologia , Xantina Oxidase/fisiologia , Xantina Oxidase/antagonistas & inibidores , Antioxidantes/farmacologia , Neutrófilos/fisiologia , Isquemia/enzimologia , Isquemia/patologia , Traumatismo por Reperfusão/enzimologia , Traumatismo por Reperfusão/patologia , Espécies Reativas de Oxigênio/metabolismo , Radicais Livres/metabolismo , Taurina/metabolismoRESUMO
Taurine (2-aminoethanosulfonic acid) appears to have an important role in cell protection against hypoxia. The mechanistic basis by which this amino acid and its derivatives are involved on these events, in brain or in other tissues, are discussed considering the antioxidant role of hypotaurine and some of its derivatives (Au)
Assuntos
Animais , Humanos , RESEARCH SUPPORT, NON-U.S. GOVT , Hipóxia Celular/fisiologia , Taurina/fisiologiaRESUMO
Taurine (2-aminoethanosulfonic acid) appears to have an important role in cell protection against hypoxia. The mechanistic basis by which this amino acid and its derivatives are involved on these events, in brain or in other tissues, are discussed considering the antioxidant role of hypotaurine and some of its derivatives
Assuntos
Animais , Humanos , Hipóxia Celular/fisiologia , Taurina/fisiologiaRESUMO
Se describen varios aspectos relacionados con el rol biológico y nutricional de la taurina y sus derivados, en células de mamíferos, con especial referencia a lo que sucede en el humano. Se analizan, además, algunos aspectos relacionados con la estructura y función de la molécula respecto a su capacidad antioxidante y osmoreguladora. Se discuten también las alteraciones que en algunos casos se pueden presentar en la distribución de este aminoácido, las cuales se producen ya sea por cambios en su biosíntesis en algunas etapas del desarrollo, o bien, por cambios a nivel del transporte en algunos tejidos donde las concentraciones están aumentadas varias veces en relación a las concentracicones plasmáticas. Existen algunas evidencias acerca de la posibilidad que la taurina pueda ser considerada como un nutriente condicionalmente esencial, en algunos casos en los que sus concentraciones en el plasma y fluidos biológicos tienen ciertas implicaciones clínicas y nutricionales
